In this free to view article in the journal Chest, an update to the 2006 Diagnosis and Management of Cough: ACCP Evidence-Based Clinical Practice Guidelines is provided by detailing the recent research, including an increasing number of studies conducted in human subjects designed to elucidate the anatomic and neurophysiologic components of cough. The article gives a clinical perspective with particular emphasis on what is known about cough in patients as well as mechanisms accounting for the excessive coughing and cough hypersensitivity associated with acute, subacute, and chronic conditions associated with cough.

Brendan J. Canning, PhD; Anne B. Chang, MBBS, PhD, MPH; Donald C. Bolser, PhD; Jaclyn A. Smith, MBChB, PhD; Stuart B. Mazzone, PhD, FCCP; Lorcan McGarvey, MD, Anatomy and Neurophysiology of Cough: CHEST Guideline and Expert Panel Report. Chest. 2014;146(6):1633-1648. doi:10.1378/chest.14-1481