Increasing evidence shows that adult type 1 diabetes mellitus (T1DM)
is associated with gaps in mental efficiency that are accompanied by structural
and functional cerebral compromise. Alterations in the brain
are typically seen in patients with peripheral complications, such as
proliferative retinopathy, which is considered to be a marker of chronic
hyperglycemia. The authors of this controlled study used neuropsychological
tests for cognitive function and magnetic resonance imaging (MRI) for white
matter integrity. They found that subclinical
macroangiopathy may be a factor in the development of diabetes-related
cognitive changes in uncomplicated T1DM. In patients with advanced T1DM,
proliferative retinopathy may be the driving force behind cerebral compromise.
Differential impact of subclinical carotid artery diseaseon cerebral structure and functioning in type 1 diabetes patients with versus thosewithout proliferative retinopathy. Cardiovascular Diabetology | Mar 12, 2014 (FREE FULL TEXT)
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