In stark contrast to the study in Nature Medicine in our previous blog entry, the summary of a new study in Mayo Clinic Proceedings is entitled, L-Carnitine significantly improves patient outcomes following heart attack : systematic review and meta-analysis. In this systematic review of controlled trials in 3,629 patients, L-carnitine was found to be associated with significant, or highly significant reduction in all cause mortality, ventricular arrhythmia and the development of angina.
Senior investigator, Carl J. Levie commented, "The Nature Medicine paper is of interest, but the main study reported there was in animals, and unlike our study, lacks hard outcomes." He also noted that there are various forms of 'carnitine'. A commentary comparing the two articles can be found on MedPage Today, New Study Questions Carnitine Heart Risk.
Mayo Clinic Proceedings, Vol 88, Issue 6 (June 2013). DOI:http://dx.doi.org/10.1016/ j.mayocp.2013.02.007. For those with access to CIAP, the issue will be available shortly with the article in full text.
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