Treatment and Management of Chronic Fatigue Syndrome

The condition known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME), also recently renamed systemic exertion intolerance disease (SEID), is a complex, heterogeneous and extremely debilitating medical condition with no known specific cause and for which no clinically established diagnostic tests are available. Its symptoms are characterized by an extreme disabling fatigue that does not improve with rest; it persists for more than 6 months, and cannot be explained by any underlying medical condition.
This review explores the current evidence on benefits and harms of therapeutic interventions in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and makes recommendations.

Castro-Marrero, J., Saez-Francas, N., Santillo, D., Alegre, J. (2017). Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome.  British Journal of Pharmacology, 174(5), 345–369. (free online)